2*-Deoxy-5-fluorouridine

Sato, Y., Utsumi, K., Maruyama, T., et al. (1994) Synthesis and hypnotic and anti-human immunodeficiency virus-1 activities of -Substituted 2 -Deoxy-2 -fluorouridines. Chem. Pharm. Bull., 42, 595-598. [Pg.194]

Cushley, R. J., Codington, J. F. and Fox, J. J. (1968) Nucleosides. XLIX. Nuclear magnetic resonance studies of 2 -and 3 -halogeno nucleosides. The conformations of 2 -deoxy-2 -fluorouridine and 3 -dcoxy-3 -(l Lioro-jl-D-arabi noliiranosyl uraci I. Can. J. Client., 46, 1131-1140. [Pg.197]

The chemical reactivity of 2 -deoxy-2 -thiouridine 3 -(p-nitrophenyl phosphate) (8), in which the 2 -hydroxyl is replaced with a 2 -thiol group, has been studied using P NMR and UV spectroscopy. Although similar to the hydrolysis of ribonucleotides, the rate of thiolate attack on the adjacent phosphatediester bond was determined to be 10 fold slower than that of the corresponding alkoxide. A study of the properties of 2 -deoxy-2 -fluorouridine 3 -(p-nitrophenyl phosphate)... [Pg.162]

Different synthetic routes have been described for synthesis of 2 -modified nucleosides [152]. 2 -Fluoro nucleosides are usually prepared starting from arabinofuranosylnucleosides. 2,2 -Anhydroarabinofuranosyluracil 61 has been reported to yield 2 -deoxy-2 fluorouridine upon treatment with hydrogen fluoride. 2 -Amino-2-deoxyuridine may be easily prepared by similar rearrangements in large scale synthesis [153]. Synthesis of 2 -deoxy-2 -fluoropurine... [Pg.286]

An enzymic synthesis of 2 -deoxy-2 -fluororibavirin (63) has been reported, involving the use of nucleoside transferase to exchange the triazole of ribavirin with the base of 2 -deoxy-2 -fluorouridine. ... [Pg.276]

Chloro-2 -deoxy- and 2 -deoxy-2 -fluorouridine labelled with... [Pg.200]

Deoxy-5-fluoro- -(3,4,5-trimethoxybenzoyl)cytidiiie, G-213 2 -Deoxy-2"-fluorouridine, D-113 2 -Deoxy-5-fluorouridine, D-114 5 -Deoxy-5-fluorouridine, D-115 3 -Deoxy-5-fluorouridine, F-18 2-Deoxy-5-fluoro-5"-uridylic acid, D-113... [Pg.1026]

Deoxy-2-fluorotalose a-D-Pyranose-/orm, D-111 2-Deoxy-2-fluorotalose p-D-Pyranose-/orm, D-111 2 -Deoxy-2 -fluorouridine, D-113... [Pg.1163]

The same yeast can also be used to prepare 3 -0-p-D-galactosyl derivatives of adenosine and inosine. Further details of the structure of adenophostins A and B have been reported.(See Vol. 27, Chap. 19, ref. 52). The cytotoxic and antimicrobial nucleoside shimofuridin A 7 has been isolated from a marine tunicate. References to AZT derivatives and to 2 -deoxy-2 -fluorouridine derivatives are made in Chapter 20. [Pg.254]

Cl3H1ftClNaOy, 2,2 -Anhydro-1- 3, 5 -di-0-acetyl-j3-D-arabinofuran-osyl -5-chloro-6-oxocytosine, 45B, 497 Cl3H15FN2O7, 3 ,5 -Diacetyl-2 -deoxy-2 -fluorouridine, 40B, 424 C13H16IN5O3, 2,3-iso-Propylidene-3,5-cycloadenosine iodide, 17, 765 C13H16N2O8, 3 ,5 -Di-O-acetyluridine, 43B, 581... [Pg.231]

MJ. Robins, K.B. Mullah, S.F. Wnuk, and N.K. Dailey, Nucleic acid related compounds. 73. Fluorination of uridine 2 -thiocthers with xenon difluoride or (diethylamino)sulfur trifluoride. Synthesis of stable 2 -[alkyl(or aryl)sulfonyl]-2 -deoxy-2 -fluorouridines,/. Org, Chem, 57 2357 (1992). [Pg.125]

An improved synthesis of 2 -deoxy-2 -fluoroadenosine has been described, involving a sequence of two inversions of configuratkMi at C-2 of an adenosine derivative, whilst the 2 -deoxy-2 -fluoroderivatives of a wide range of purine nucleosides have been made by glycosyl transfn 6tMn 2 -deoxy-2 -fluorouridine uring diymidine phosphorylase and purine nucleoside phosphc lase. ... [Pg.248]

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