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15-Deoxy-A12,14-prostaglandin

In a similar manner, Brummond et al. demonstrated the first total synthesis of 15-deoxy-A12,14-prostaglandin J2 (162) that was completed using a silicon-tethered allenic Pauson-Khand reaction to obtain the highly unsaturated cyclopentenone substructure [36]. Treatment of alkynylallene 160 with molybdenum hexacarbonyl and dimethyl sulfoxide affords the desired cycloadduct 161 in 43% yield (Scheme 19.30). Trienone 161 was obtained as a 2 1 Z E mixture of isomers in which the Z-isomer could be isomerized to the desired E-isomer. The silicon tether was cleaved and the resulting product converted to 15-deoxy-A12,14-prostaglandin J2 (162). [Pg.1062]

Peroxisome proliferator-activted receptor, PPAR 15-Deoxy-A12,14-prostaglandin J2 AGGTCA DR-1... [Pg.150]

See other pages where 15-Deoxy-A12,14-prostaglandin is mentioned: [Pg.1062]    [Pg.179]    [Pg.172]    [Pg.121]    [Pg.121]    [Pg.152]    [Pg.189]    [Pg.1062]    [Pg.179]    [Pg.172]    [Pg.121]    [Pg.121]    [Pg.152]    [Pg.189]    [Pg.1002]    [Pg.1002]   
See also in sourсe #XX -- [ Pg.2 , Pg.247 , Pg.545 ]



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15-Deoxy-<5 -prostaglandin

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