Dendronized Supports in Separation Processes

The potential of dendronized supports to serve as stationary phases for various separation techniques has been explored by a number of research groups. One of the most important applications in this field is the use of dendron-modified support as chiral stationary phase (CSP) for separation of enantiomers. An unsuccessful attempt to do so was reported by Mitchell and coworkers, who used poly-L-glutamate dendrons postsynthetically immobilized on silica.  

The use of dendronized polymers as CSPs was successfully established by Frechet and coworkers. The polymer-bound polyester dendrons (not chiral themselves, see Section 

DENDRITIC MOLECULES ON SOLID SUPPORT SOLID-PHASE SYNTHESIS AND APPLICATIONS 

The use of dendronized silica as a stationary phase in capillary gas chromatography was pioneered in 2001 by Newkome et al., who used the triply branched dendrons prepared in solution and immobilized on fused silica inside the capillary column. The dendritic architecture provides unique selectivity in separation of a Grob test mixture of compounds. The same dendron-silica hybrids were used by the authors for solventless capillary microextraction (CME) and preconcentration in chemical analysis. 

Su and coworkers used silica gel with immobilized polymelamine, poly(amidoamine), or poly(propylenimine) dendrons as the microcolumn packing for the flow injection preconcentration and separation of traces of Pt(IV) ions for flame atomic absorption spectroscopy determination.Polyamine dendron-functionalized polystyrene was 

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