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Dendrobines convulsants

Chen et al. state that dendrobine produces moderate hyperglycemia, diminishes cardiac activity in large doses, lowers blood pressure, depresses respiration, inhibits isolated rabbit intestine and contracts isolated guinea-pig uterus. It has a weak analgesic, antipyretic action. Chen and Rose found that the convulsions induced by injection of dendrobine can be controlled by use of sodium isoamylethylbarbiturate they appear to be central in origin due to action on the cord and medulla. [Pg.724]

Although Dendrobium species are much better known as ornamental plants and for their use in traditional medicine, their alkaloids, the dendrobines, are also convulsants (2). The effects of dendrobinium chloride intoxication resemble more those of strychnine intoxication than those of picrotoxinin intoxication (240). The minimal lethal dose (intravenous) in rats and mice is 20 mg/kg. The toxicity of the picrotoxanes is attributable to their ability to overcome the blood-brain barrier and to bind to inhibitory Cys-loop receptors of the postS3napses of the CNS. [Pg.190]

Dendrobine, a congener of the powerful convulsant picrotoxinin, was first isolated from the Chinese tonic Chin Shih Hu in 1932, but its complete structure was not unravelled until 1964. Three groups of workers have reported the synthesis of dedrobine since that time. The synthesis outlined below was developed by Kende and his group at Rochester, and is based on the c/s-hydroindan nucleus (B) derived from the Diels-Alder adduct (A) by cleavage and aldol cyclization. The hydroindan derivative (B) already carrying the isopropyl unit, bears appropriate functionality for elaboration of the N-methylpyrrolidine ring and the 7-lactone moiety. [Pg.90]


See also in sourсe #XX -- [ Pg.190 ]




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