Dendritic box shape-selective liberation of encapsulated

Jansen, J.F.G.A., De Brabander-Van Den Berg, E.M.M., and Meijer, E.W. (1994a) The dendritic box shape-selective liberation of encapsulated guests. Journal of the American Chemical Society, 117,4417. 

The diffusion of entrapped guest molecules out of dendritic boxes was un-measurably slow over a period of several months. However, Meijer and coworkers have demonstrated that the shape-selective liberation of encapsulated guests could be achieved by removing the closed shell in two steps (Scheme 3) [15]. First, hydrolysis of the tBOC groups of the dense shell with formic acid gave a partly open dendritic box . At this point, small guests such as p-nitroben-zoic acid and nitrophenol could diffuse out of the box by dialysis. Susequent and complete removal of the outer shell by refluxing with 12 AT HC1, lead to the... 

We have discussed the synthesis of dendritic boxes possessing a unimolecular compartmented structure in which guest molecules are physically locked. Evidence is presented that the encapsulation is dominated by the architecture of the dendrimer and that some supramolecular ordering is present. Furthermore, a shape-selective liberation of guests can be accomplished by a two-step process. 

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