Dendrimers diagnostic

Krause W, Hackmann-Schlichter N, Maier FK, Muller R (2000) Dendrimers in Diagnostics. 210 261-308... 

Dendrimer-based Biological Reagents Preparation and Applications in Diagnostics... 

The methods developed by us for preparation of these dendrimer-based reagents are quite general and have the potential of application to a large variety of molecules that have utility in diagnostics, therapeutics, biocatalysis, enzymol-ogy and food processing industry. 

Kozhushkov SI, see de Meijere A (2000) 207 149-227 Krause W (2002) Liver-Specific X-Ray Contrast Agents. 222 173-200 Krause W, Hackmann-Schlichter N, Maier FK, Mller R (2000) Dendrimers in Diagnostics. 210 261-308... 

The multivalency of peptide dendrimers has also been used to increase the binding avidity of antigens to antibodies in various immunological assays and diagnostic tests. 27,43,47,48,55-59 Examples in the literature have been reported where the MAP format increases the binding avidity and sensitivity, in some cases >100000 fold. In addition to immunology, MAP types of dendrimers have found applications in areas such as inhibitors, 44,45,51,60,61 artificial proteins, 62 affinity purification, 63 and intracellular transportation, 41 as well as in drug discovery. 53 ... 

The third International Dendrimer Symposium took place at Berlin Technical University in 2003. Interdisciplinary lectures demonstrated the extent to which dendritic molecules branch ouf into other areas of science, such as physics, biology, medicine, and engineering. The possibilities of functionalisation and resulting applications in industry were at the focus of this symposium. For example, nano-dimensioned dendrimer-based contrast agents were presented as multilabels for visualisation of blood vessels (see Chapter 8). Potential applications of dendritic materials as luminescence markers in diagnostics attracted lively interest (see Chapter 8). Consideration of the differences between dendrimers and hyperbranched polymers from the viewpoint of their cost-favourable application was also a topic of discussion [18]. 

Dendrimers are seen to have applications in medicine, especially in diagnostics [57 a]. Apart from good solubility in water, the possibility of introducing multiple special functionalities into the periphery of the nanoscale molecules permits high sensitivity to be attained and variation of the parameters over a wide range as required by the prevailing conditions. 

Koser GF (2003) C-Heteroatom-Bond Forming Reactions.224 137-172 Koser GF (2003) Heteroatom-Heteroatom-Bond Forming Reactions. 224 173-183 Kosugi M, see Fugami K (2002) 219 87-130 Kozhushkov SI, see de Meijere A (1999) 201 1 - 42 Kozhushkov SI, see de Meijere A (2000) 207 89-147 Kozhushkov SI, see de Meijere A (2000) 207 149-227 Krause W (2002) Liver-Specific X-Ray Contrast Agents. 222 173-200 Krause W, Hackmann-Schlichter N, Maier FK, Muller R (2000) Dendrimers in Diagnostics. 210 261-308... 

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