Dehydrotumulosic acid

The anti-inflammatory effect of pachymic and dehydrotumulosic acids was determined in vivo against mouse PLA2 paw edema. At a dose of 50 mg/kg i.p., both were active (54% and 57% inhibition, respectively). As it has been proved that this model involves a release of histamine and 5-HT, an antagonism with one or both of these amines might occur, although this... 

The anti-inflammatory activity of the hydroalcoholic extract of P. cocos against some acute and chronic inflammatory processes was established recently. It reduced the TPA-induced edema (80% inhibition at 0.5 mg/ear), but its effect was milder against the AA-induced ear edema (40% inhibition at 0.5 mg/ear). When the extract was assayed in chronic experimental model of inflammation, it caused a 53% reduction in ear thickness together with a 73% decrease in myeloperoxidase (MPO) activity, which shows that leukocyte infiltration into the inflammation site could be prevented by a repeated dose of 1 mg/ear. The main constituents isolated from the extract were identified as pachymic and dehydrotumulosic acids. Topical administration of these lanostanes inhibited the TPA-induced edema with ID50 of 2.48 and 0.31 pg/ear, respectively. Reasons for the greater activity of dehydrotumulosic acid... 

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