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Steroids dehydrogenation

In an interesting extension of the use of benzeneseleninic anhydride. Barton and coworkers ° have dehydrogenated steroidal and other oxazolines e.g. 25) in high yield (equation 13). This type of reaction has considerable potential for a wide variety of heterocyclic systems, due to the acidity of exocyclic... [Pg.132]

Sobering investigators uncovered a second significant breakthrough in microbial biotechnology of steroid production. They discovered that Corynebacterium simplex converted hydrocortisone (cortisol) (29) to prednisolone via a 1,2-dehydrogenation reaction. This A -3-ketosteroid is a highly active antiinflammatory commercial product (162). [Pg.430]

A third advancement in microbial biotechnology of steroid production was the abiUty to introduce a 16a-hydroxyl group microbiologicaHy (163). Modifications of the liP-hydroxylation, 16a-hydroxylation 1,2-dehydrogenation microbial processes are used for the synthesis of hydrocortisone, prednisolone, triamcinolone, and other steroid pharmaceuticals. A few microbial transformations that have been used to manufacture steroids are Hsted in Table 1 (164). [Pg.430]

Selenium dioxide was first employed in steroid dehydrogenation for the direct formation of 12-ketones in corticoid synthesis. This dehydroge-... [Pg.318]

Concomitantly, additional transformations may occur at other parts of the steroid nucleus, e.g., 1,2-dehydrogenation, 6 - or 9a-hydroxylation. ... [Pg.147]

DDQ had been used extensively in the dehydrogenation of 3-keto steroids under neutral or... [Pg.85]

Related dehydrogenation processes are known as in the aromatization of the A ring of steroids, which was achieved by using the Cp Ru+ fragment. Such a process occurs via a series of C-O, C-H and C-C bond activations (Equation (24)).34... [Pg.110]

Sterilization, in fermentation, 11 35-36 Sterilization-in-place (SIP), 11 40 Stern-Langmuir equation, 24 139 Stern-Langmuir isotherm, 24 138 Stern plane, 7 285-286 Steroidal ketones, dehydrogenation of,... [Pg.887]

A vast amount of research resulted in the improvement of this bioconversion, as well as the development of many other microbiological reactions. Some of these include Ci-dehydrogenation, C 6-a-hydroxylation, and Cj i-P-hydroxylation of steroids [45-52]. Other... [Pg.181]


See other pages where Steroids dehydrogenation is mentioned: [Pg.145]    [Pg.145]    [Pg.145]    [Pg.276]    [Pg.145]    [Pg.145]    [Pg.145]    [Pg.276]    [Pg.283]    [Pg.65]    [Pg.310]    [Pg.310]    [Pg.408]    [Pg.432]    [Pg.246]    [Pg.247]    [Pg.306]    [Pg.315]    [Pg.413]    [Pg.320]    [Pg.33]    [Pg.179]    [Pg.200]    [Pg.363]    [Pg.230]    [Pg.53]    [Pg.110]    [Pg.376]    [Pg.376]    [Pg.685]    [Pg.706]    [Pg.60]    [Pg.280]   


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