Dehydrogenases phosphogluconate dehydrogenase

Pentose phosphate shunt Glucose-6-phosphate dehydrogenase Phosphogluconate dehydrogenase Transketolase Transaldolase... 

The dehydrogenase catalysing the glucose-6-phosphate to 6-phosphogluconate step is specific for the phosphorylated derivative of gluconate. 

Bishop, C. Assay of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in red cell. J. 

Dehydrogenation of 6-phosphogluconate to ribulose 5-phosphate. This reaction is catalyzed by 6-phosphogluconate dehydrogenase according to the scheme ... 

G10. Glock, G. E., and McLean, P., Further studies on the properties and assay of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase of rat liver. Biochem. ]. 55, 400-408 (1953). 

M12. McNair Scott, D. B., and Cohen, S. S., The oxidative pathway of carbohydrate metabolism in Escherichia coli. 5. Isolation and identification of ribulose-5-phosphate produced from 6-phosphogluconate by the dehydrogenases of Escherichia coli. Biochem. J. 65, 686-689 (1957). 

W18. Wolfson, S. K., Jr., and Williams-Ashman, H. G., Isocitric and 6-phosphogluconic dehydrogenases in human blood serum. Proc. Soc. Exptl. Biol. Med. 96, 231-234 (1957). 

Dehydrogenase, 6-Phosphogluconate Dehydrogenase, Glutathione Reductase, Methemoglobin Reductase, Polyol Dehydrogenases (Bruns and Werners), 5, 237... 

The three reactions are catalysed by glucose 6-phosphate Glucose enters the blood from three different sources dehydrogenase, gluconolactonase and phosphogluconate depending on the conditions. 

The enzyme, 6-phosphogluconolactonase, catalyses the hydrolysis of this product to form phosphogluconate. The oxidation of the phosphogluconate, in a reaction catalysed by phosphogluconate dehydrogenase, generates the second NADPH molecule ... 

The last enzyme in the oxidative part is phosphogluconate dehydrogenase [3], which releases the carboxylate group of 6-phosphogluconate as CO2 and at the same time oxidizes the hydroxyl group at C3 to an 0x0 group. In addition to a second NADPH+H", this also produces the ketopentose ribulose 5-phosphate. This is converted by an isomer-ase to ribose 5-phosphate, the initial compound for nucleotide synthesis (top). 

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