Dehydroepiandrosterone sulfate function

SULT 1B1 functions in the sulfation of diverse endogenous substrates include cholesterol, dehydroepiandrosterone (DHEA), thyroid hormone, and dopamine. The enzyme also contributes to the metabolism of phenolic xenobiotics such as those containing 2-naphthol. It is highly expressed in the liver, colon, small intestine, and blood leukocytes. 

Adrenocortical steroid hormones have a vast array of biological functions. Cortisol, the primary human glucocorticoid, regulates the inflammatory response (Newton and Holden, 2007), carbohydrate and lipid metabolism, and stress response (Kassel and Herrlich, 2007). Aldosterone regulates blood pressure by modulating fluid and electrolyte balance (Brizuela et ah, 2006 Foster, 2004). In the adrenal cortex, dehydroepiandrosterone (DHEA), dehy-droepiandrosterone sulfate (DHEA-S), and androstenedione are the androgens produced (Havelock et ah, 2004 Rainey et ah, 2002). 

Nature Dehydroepiandrosterone (DHEA), derived mainly from the adrenal cortex, is an androgen precursor and in peripheral tissues is converted by aromatase to estradiol, fit the plasma, DHEA is converted to DHEA sulfate (DHEAS). No specific physiologic function has been defined for DHEA or DHEAS. However, DHEA levels decrease during aging and possibly in some disease states, including advanced AIDS, diabetes, and systemic lupus erythematosus (in women). 

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