Dehalogenases reductive

Magnuson JK, ME Romine, DR Burris, MT Kingsley (2000) Trichlorethene reductive dehalogenase from Dehalococcoides ethenogenes. squence of tceA and substrate characterization. Appl Environ Microbiol 66 5141-5147. 

Maillard J, W Schumacher, F Vazquez, C Regeard, WR Hagen, C Holliger (2003) Characterization of the corrinoid iron-sulfur protein tetrachloroethene reductive dehalogenase of Dehalobacter restrictus. Appl Environ Microbiol 69 4628-4638. 

Miller E, G Wohlfarth, G Dielkert (1998) Purification and characterization of the tetrachloroethene reductive dehalogenase of strain PCE-S. Arch Microbiol 169 497-502. 

Neumann A, A Siebert, T Trescher, S Reinhardt, G Wohlfarth, G Dickert (2002) Tetrachloroethene reductive dehalogenase of Dehalospirillum multivorans substrate specificity of the native enzyme and its cor-ronoid cofactor. Arch Microbiol 111 420-426. 

Suyama A, M Yamashita, S Yoshino, K Furukawa (2002) Molecular characterization of the PceA reductive dehalogenase of Desulfitobacterium sp. strain Y51. J Bacteriol 184 3419-3425. 

Ni S, JK Fredrickson, L Xun (1995) Purification and characterization of a novel 3-chlorobenzoate-reductive dehalogenase from the cytoplasmic membrane of Desulfomonile tiedje DVCB-1. J Bacteriol Yll 5135-5139. 

Xun L, E Topp, CS Orser (1992c) Purification and characterization of a tetrachloro-p-hydroquinone reductive dehalogenase from a Flavobacterium sp. J Bacterial 174 8003-8007. 

Krasotkina J, T Walters, KA Maruya, SW Ragsdale (2001) Characterization of the Bjj- and iron-sulfur-containing reductive dehalogenase from Desulfitobacterium chlororespirans. J Biol Chem 276 40991-40997. 

Thibodeau J, A Gauthier, M Duguay, R Villemur, F Lepine, P Juteau, R Beaudet (2004) Purification, cloning, and sequencing of a 3,5-dichlorophenol reductive dehalogenase from Desulfitobacterium frappieri BCP-l. Appl Environ Microbiol 70 4532-4537. 

Uotila JS, VH Kitunen, T Saastamoinen, T Coote, MM Hagblom, M Salkinoja-Salonen (1992) Characterization of aromatic dehalogenases of Mycobacterium fortuitum CG-2. J Bacteriol 174 5669-5675. van der Tweel WJJ, JB Kok, JAM de Bont (1987) Reductive dechlorination of 2,4-dichlorohenzoate to 4-chlorobenzoate and hydrolytic dehalogenation of 4-chloro-, 4-hromo-, and 4-iodohenzoate hyAcalig-enes denitrificans NTB-1. App/ Environ Microbiol 53 810-815. 

The dehalogenases (EC 3.8.1), a subclass of the hydrolases that act on the halide bonds in C-halide compounds, catalyze reactions of hydrolytic de-halogenation (Fig. 11.3,a), i.e., the replacement of a halide atom at a sp3 C-atom with a OH group. Exceptions include thyroxine deiodinase (EC 3.8.1.4), which catalyzes reductive deiodination on phenyl rings, and the bacterial 4-chlorobenzoate dehalogenase (EC 3.8.1.6), which forms 4-hydroxy-benzoate. 

Some examples of emerging enzyme classes that are rapidly making an impact in synthetic organic chemistry are shown in Figure 16.4 alcohol dehydrogenase for the reduction of ketones [30], transaminase [31], and haloalkane dehalogenase... 

Magnuson, J. K., M. F. Romine, D. R. Burris, and M. T. Kingsley, Trichloroethene reductive dehalogenase from Dehalococcoides ethenogenes. Sequence of tceA and substrate range characterization , Appl. Environ. Microbiol., 66, 5141-5147 (2000). 

Neumann, A., G. Wohlfarth, and G. Diekert, Purification and characterization of tetrachloroethene reductive dehalogenase from Dehalospirillum multivorans , J. Biol. Chem., 271, 16515-16519 (1996). 

Wohlfarth, G., and G. Diekert, Reductive dehalogenases . In Chemistry and Biochemistry ofB12, R. Banerjee, Ed., Wiley-Interscience, New York, 1999, pp. 871-893. 

Krautler B, Fieber W, Ostermann S, Fasching M, Ongania K-H, Gruber K, Kratky C, Miki C, Siebert A, Diekert G (2003) The Cofactor of Tetrachloroethene Reductive Dehalogenase... 

Christiansen N, Ahring BK, Wohlfarth G, Diekert G (1998) Purification and Characterization of the 3-Chloro-4-hydroxy-phcnylacetate Reductive Dehalogenase of Desulfitobacte-rium hafniense. FEBS Lett 436 159... 

Robert, M. and Saveant, l.-M. (2005) Electroenzymatic reactions. Investigation of a reductive dehalogenase by means of electrogenerated redox cosubstrates. 1. Am. Chem. Soc. 127, 13583-13588. 

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