Degradation in cells

Stage 2 Fatty acids, monosaccharides, and amino acids are degraded in cells to yield acetyl CoA. 

Smaller peptides are difficult to overexpress in E. coli and are additionally degraded in cells. These problems are commonly circumvented if fusion peptides are used from... 

For many years, I have been interested in the problem of how proteins are degraded in cells. The dynamic state of cellular proteins (Schoenheimer, 1942) and the important roles of protein degradation in the control of cellular enzyme levels (Schimke Doyle, 1970) have been recognized for a long time, but the underlying molecular mechanisms remained unknown. A clue to an unusual mechanism was provided by observations indicating that the... 

Hershko, A. (1997). Roles of ubiquitin-mediated protein degradation in cell cycle control. Curr. Op. Cell Biol. 9, 788-799. 

The first stage of catabolism, digestion, takes place in the stomach and small intestine when bulk food is broken down into small molecules such as simple sugars, long-chain carboxylic acids (called fatty acids), and amino acids. In stage 2, these small molecules are further degraded in cells to yield two-carbon acetyl... 

Proteins are degraded in cells by various systems, including the ubiquitin-depend-ent pathway, macroautophagy and microautophagy. Ubiquitjn, a small protein of 76 amino acids, is attached to damaged or abnormal proteins by means of an ATJ dependent reaction. The ubiquitin molecule serves as a tag that directs the faulty protein to be hydrolyzed by a particle called the pnoleasome. 

Proteins are degraded in cells. What is ubiquitin, and what role does it play in tagging proteins for degradation What is the role of proteasomes in protein degradation ... 

Although the proteases involved in nonlysosomal ubiquitin-dependent protein degradation are not well characterized, the site of protein degradation in cells ap-... 

A trace of SO2 can cause a significant degradation in PEM fuel cell performance. As shown in Figure 6.6 [34], after the PEM fuel cell was exposed to 1 ppm S02/air for 100 hours at 70 °C at a current density of 0.5 A/cm, 35% degradation in cell performance was observed, with a cell voltage decrease from 0.68 V to 0.44 V. 

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