Degradation behaviour of drug-releasing

Milroy, G. E. in Degradation and drug release behaviour of polyglycolide (PhD thesis. University of Cambridge, Cambridge, 2001). 

Noorsal et al. (2005) used polymer discs made from Maxon for controlled drug release. The authors observed different drug release behaviours related to degradation first by diffusion, and then by micropores and erosion of the matrix. No burst effect was observed. 

Blends of chitosan and PEG were prepared and characterised for controlled release of drugs. Structural studies of beads were performed using FTIR and SEM. The swelling behaviour, solubility, hydrolytic degradation and loading capacity of the beads for isoniazid were investigated. 25 refs. 

In this work we will focus on the use of the cubic phase as a delivery system for oligopeptides - Desmopressin, Lysine Vasopressin, Somatostatin and the Renin inhibitor H214/03. The amino acid sequences of these peptides are given in Table I. The work focuses on the cubic phase as a subcutaneous or intramuscular depot for extended release of peptide drugs, and as a vehicle for peptide uptake in the Gl-tract. Several examples of how the peptide drugs interact with this lipid-water system will be given in terms of phase behaviour, peptide self-diffusion, in vitro and in vivo release kinetics, and the ability of the cubic phase to protect peptides from enzymatic degradation in vitro. Part of this work has been described elsewhere (4-6). 

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