Deficiency dietary purines,effect

HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HGPRT) DEFICIENCY EFFECT OF DIETARY PURINES ON ENZYME ACTIVITY... 

Tn recent years there has been an increased interest in assessing the human health effects from environmental exposure to trace metals. Studies of occupational exposures and dietary intakes of trace metals have required the refinement and development of analytical techniques for the analyses of low elemental concentrations in complex matrices. Molybdenum is one of the trace metals that has been the subject of intensive study because it is an essential trace element in both plant and animal nutrition. It is an integral constituent of several metalloenzymes including xanthine oxidase, which is the last enzyme in the catabolic pathway of purines. Extensive ingestion of molybdenum has been shown to cause molybdenosis in cattle. Many of the features of this condition can be ascribed to induced copper deficiency. Whether biochemical changes or adverse health effects in humans can be attributed to excessive exposure to molybdenum is not known. 

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