Bone dysplasia deferoxamine

Two Chinese studies in 35 consecutive patients with thalassemia on a hypertransfusion scheme plus chelation therapy have confirmed that deferoxamine-induced bone dysplasia was associated with height reduction and occurred at doses below 50 mg/kg/day (107,108). 

In the first study, the patients had radiography of the left hand for bone age determination, and 12 had deferoxamine-induced long bone dysplasia (107). There was irregularity at the physeal-metaphyseal junction of the distal ulna (the site most frequently affected) and radius metaphyseal sclerosis was also common, especially of the ulna, but also of the radius, metacarpals, and phalanges. Radiolucent lesions occasionally accompanied metaphyseal sclerosis. In six patients with relatively mild lesions, the dysplastic changes had been missed or not mentioned. 

The following strategy may be helpful in preventing bone dysplasia during treatment with deferoxamine (105,106) ... 

Brill PW, Winchester P, Giardina PJ, Cunningham-Rundles S. Deferoxamine-induced bone dysplasia in patients with thalassemia major. Am J Roentgenol 1991 156(3) 561-5. 

Miller TT, Caldwell G, Kaye JJ, Arkin S, Burke S, Brill PW. MR imaging of deferoxamine-induced bone dysplasia in an 8-year-old female with thalassemia major. Pediatr Radiol 1993 23(7) 523-4. 

Chan Y, Li C, Chu WC, Pang L, Cheng JC, Chik KW. Deferoxamine-induced bone dysplasia in the distal femur and patella of pediatric patients and young adults MR imaging appearance. Am J Roentgenol 2000 175(6) 1561-6. 

Musculoskeletal In a retrospective series of 84 children receiving deferoxamine for trans-fusion-related hemochromatosis (P-thalasse-mia, E/p-thalassemia, or a-thalassemia) bone dysplasia occurred in 17 [39 ]. The standard dose was 25-50 mg/kg/day subcutaneously over 10 hours on 5-7 nights a week three patients received short-term intravenous deferoxamine at some point during the study. 

Danaparoid sodium, 32.631 Daptomycin, muscle damage, 30.309 Deferiprone, cardiac siderosis, 29.235 Deferoxamine, 16.247 bone dysplasia, 23.241 cardiac siderosis, 29.235 bone dysplasia, 23.241 cardiac siderosis, 29.235 yersiniosis, 11.215... 

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