Foods Deferasirox

In a recent patent application, mice treated with a related iron chelator, deferasirox (DFS), showed reduced body weight while on a high fat diet compared to untreated controls. Additionally, DFS was claimed to improve whole body metabolism and energy expenditure as measured by increased 02 consumption and C02 production as well as a reduction in white adipose and visceral fat, despite little difference between food intake in the control and treated animal groups [25]. 

Deferasirox did not alter the pharmacokinetics of digoxin. Food increases the bioavailability of deferasirox, and it should be taken on an empty stomach. The use of deferasirox with aluminium antacids is not recommended. Rifampicin, phenobarbital and pheny-toin are predicted to increase the metabolism of deferasirox, and, until more is known, concurrent use should be monitored. Based on in vitro data, deferasirox might inhibit the metabolism of CYP2C8 substrates like paclitaxel and repaglinide. Hydroxycar-bamide does not alter deferasirox metabolism. 

Food increased the bioavailability of deferasirox to a variable extent, and the manufacturer recommends that it is taken on an empty stomach at least 30 minutes before food. - The tablets for oral suspension ean be dispersed in water, orange juice, or apple juice. ... 

USA Food and Drug Administration. Exjade (deferasirox) Boxed Warning. 18 February 2010. http //www.fda.gov/Safety/ MedWatch/Safetylnformation/SafetyAlerts-forHumanMedicalProducts/ucm200850.htm. 

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