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Decoupled, NOE Double Resonance and COSY Spectra

If it is not obvious which protons in a molecule are coupled to which, [Pg.83]

The acronym COSY stands for Correlated SpectroscopV and this technique is widely used to determine all of the coupling interactions in a single experiment. This proves to be more efficient than the decoupling experiment in which each signal is irradiated in turn to determine its coupling partners. COSY involves a multiple pulse sequence (which we do not need to know anything about in order to use the technique) and is an example of two-dimensional (2D) spectroscopy. [Pg.85]

As all the coupling relationships in the molecule are given in the COSY spectrum, it is normal to be able to deduce all of the structural fragments in a molecule from the HH COSY spectrum. [Pg.86]

The % enhancement is found by dividing the height of ihe integral for the peak of interest by the value for IH. and multiplying by 100 For the peak at fi 4 42. this gives an enhancement of 5,9% (the maximum value is 50% but usual values are between 1 and 20%.  [Pg.87]

Once again, there is a 2D version of this experiment which gives all [Pg.87]


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And decoupling

COSY

COSY spectrum

Decoupled spectra

Decoupler

Decouplers

Decoupling

Decoupling and Double resonance

Decouplings

Double resonance

NOE

NOE spectrum

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