Decarboxylative coupling reaction

One typical radical reaction is a coupling reaction. Oxidative decarboxylation coupling reaction of carboxylic acids by electrolysis (Kolbe electrolysis), intramolecular coupling reaction of diesters with Na (acyloin condensation), formation of pinacols from ketones or aldehydes with Na or Mg are well known classical methods [1,2]. Recently, oxidative... 

Scheme 1.40 Proposed catalytic cycle for the Pd-catalyzed decarboxylative coupling reaction of Park et al.

In Chapter 3, the authors present a general overview on decarboxylative coupling reactions catalyzed by transition-metal catalysts. This is actually a very short chapter. 

SCHEME 4.357 Synthesis of alkynylphosphine oxides through a decarboxylative coupling reaction [482]. 

Huang et al. described paUadium/copper-cocatalyzed cascade halopalladation/ decarboxylation/carbon-carbon fonning reactions for the synthesis of 5-halo-6-substituted benzo[it]naphtho[2,l-d]furans 267 [95] (Scheme 6.71). The protocol represents the first example of trapping the a-vinylpalladium intermediate, generated from halopalladation of alkynes, by the decarboxylative coupling reaction. 

A copper/A,A-diisopropyl-ethylamine (DIPEA)-catalyzed, aldehyde-induced intermolecular decarboxylative coupling reaction of proline and... 

Reactions of phosphonic acids and their derivatives A copper catalysed intermolecular, decarboxylative coupling reaction of natural a-amino acids (583) and phosphites or secondary phosphine oxides (584) with aldehydes (585), has been developed in the synthesis of unnatural amino acid derivatives (586) (Scheme 145). ... 

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