Decamethonium Vecuronium

Prior administration of decamethonium 100 micrograms/kg caused a sevenfold increase in sensitivity to vecuronium (reducing the ED50 from 24 to 3.5 micrograms/kg). ... 

CampkinNTA, Hood JR, Feldman SA, Resistance to decamethonium neuromuscular block after prior administration of vecuronium, AnesthAnalg (1993) 77, 78-80,... 

Category 2. Antibodies with recognition profiles confined to the ammonium groups but which cross-react with, and are inhibited almost equally well by, each of the NMBDs with the same or similar groups linked to the nitrogens. Examples include succinylcholine and decamethonium rf-mbocurarine and atracurium and pancuronium and vecuronium. However, since differences occur in the structures attached to the nitrogens in some NMBDs, antibodies to one NMBD, for example, succinylcholine, may not readily cross-react with, and be inhibited by, some other NMBDs, for example, rocuronium. 

Neuromuscular blocking drug (NMBD) or analog—choline for succinylcholine and decamethonium triethylcholine for gallamine Drug or analog covalently coupled to Sepharose Vecuronium produced 50 % inhibition at 0.2 nmol/tube... 

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