Darnel

Taumel, m. reeling giddiness intoxication transport, frenzy, -beweguag, /. (Mach.) tumbler motion, -kom, n. darnel (Lolium temulentum). 

Darnell, J., Lodish, H., Baltimore, D. (1986). Molecular Cell Biology. W.H. Freeman, New York. 

Darnell, J.E. Transcription factors as targets for cancer therapy. Nature Rev. Cancer 2002, 2, 740-749. 

Darnell JE Jr, Kerr IM, Stark GR Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994 264 l4l5. 

H. Lodish, D. Baltimore, A. Berk, S. L. Zipursky, P. Matsudaira, J. Darnell, Molecular Cell Biology, W. H. Freeman and Company, 1995. 

Lai, E., Prezioso, V. R., Tao, W., Chen, W. S., and Darnell, J. E. (1991). Hepatocyte nuclear factor 3a belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes Dev. 5 416-427. 

Miyashiro et al., 2003), the validation of these targets whose translation is important for plasticity in vivo remains to be demonstrated (Darnell etal., 2005). 

Darnell, J. C., Mostovetsky, O., and Darnell, R. B. (2005). FMRP RNA targets Identification and validation. Genes Brain Behav. 4, 341-349. 

Let us continue with the example of copper ions in contact with copper metal and zinc ions in contact with zinc metal. This combination is usually referred to as the Darnell cell or zinc/copper couple(Fig. 6.5a). For this electrochemical cell the reduction and oxidation processes responsible for the overall reaction are separated in space one half reaction taking place in one electrode compartment and the other takes place in the other compartment. 

The original solids-conveying model developed by Darnel and Mol [7] assumed that the pressure (or stress) in the solid bed is isotropic. This assumption was made to simplify the mathematics and because of the lack of stress data for solid bed compacts. Previous research, however, showed that stresses in solid compacts are not isotropic [8]. Anisotropic stresses can be represented by the lateral stress ratio. It is defined as the ratio of the compressive stress in the secondary direction to the compressive stress in the primary direction, as shown in Fig. 4.7 and Eq. 4.1. 

Darnell and Mol neglected the width of the flight (e = 0) so the formulation of was reduced in their model as follows ... 

Like the original Darnell-Mol model, the Tadmor-Kleln model was developed with only very limited rate data because solids conveying measuring devices were not available at that time. Moreover, dynamic coefficient of friction data were also unavailable during their model developments. Complete plastlcatlng extrusion simulations, however, were developed with the Tadmor-Kleln model using engineering friction coefficients to estimate the characteristics in the process. 

Unlike the previous models by Darnell and Mol [14] and Tadmor and Klein [1], which are based upon the assumption of isotropic stress conditions, Campbell s model [20] considered anisotropic stress conditions, as suggested by Schneider [15], but it was assumed to be 1.0 due to the lack of published experimental data on the subject. Variations on the model set forth by Campbell and Dontula [20] include a modification to incorporate the lateral stress ratio [19, 22], and other modifications discussed by Hyun et al. [21, 23]. A modified Campbell-Dontula model with a homogeneous lateral stress is as follows ... 

Hyun et al. [21] evaluated both the original model by Darnell and Mol [14] and the model by Campbell and Dontula [19] for accuracy against experimental data, and determined that the Darnell-Mol model was less accurate than that of the Campbell-Dontula model. The incorporation of the lateral stress ratio in the calculations supported their conclusions even more. At the time of the work by Hyun et al, however, the physics for screw rotation was not well appreciated, and the evaluations for the Campbell models [23] were performed with coefficient of friction... 

Fuel Cells for Portable Power Markets, Manufacture and Cost, Darnell Group Inc. 2003. 

Thanks go to Paul Anderson, Frank Ascione, Jerome Bimbaum, Lewis Cantley, Jennifer Darnell, Robert Darnell, Bink Garrison, Lori Morton, Mark Murcko, Larry Stemson, and Leslie Vosshall. I am also indebted to Bonnie Bassler, Milos Novotny, and Charles Wysocki who provided reprints and preprints of manuscripts covering important work cited in this book. Aspects of the structure of chapters 3-6 derive in part from a general chemistry textbook that I coauthored with Riley Schaeffer many years ago and thanks are due to Riley for his contributions. 

Levy DE, Darnell JE, Jr. (2002). Stats transcriptional control and biological impact. Nat Rev Mol Cell Biol 3 651-662. 

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