DARC-PELCO approach

The DARC-PELCO approach [418—423] is a simple application of a hyperstructure concept to the Free Wilson method while the approach may be appropriate for extremely large data sets, e.g. for the derivation of lipophilicity contributions from partition coefficients, it is usdess for most structure-activity analyses, due to the much too large number of variables (compare eqs. 199 and 200, chapter 8) [390, 391]. The results from Hansch, Free Wilson, and DARC-PELCO analyses have been compared with each other [421, 422, 424] no advantages of the latter approach could be seen. 

An example of the application of the DARC-PELCO approach is given in eq. 199 (PC = phenol coefficient) [421], which describes the antibacterial activities of linear and branched alcohols (54) however, the result is trivial, because the compounds... 

In the DARC/PELCO Structural method an internal variable pertaining to the ordered generation of an exhaustive topology is used. We show to what extent this variable combines some qualities of other structural variables, avoids some of their drawbacks and permits an approach to prediction reliability ... 

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