DARC-EPIOS

Dubois et al. developed the Description, Acquisition, Retrieval, Computer-aided design-Elucidation by Progressive Intersection of Ordered Structures (DARC-EPIOS) system for structural elucidation.Their approach was based on C spectra. These were predicted using an additive method, but based on their DARC descriptor of environment, as opposed to the more common HOSE code. The EPIOS system was designed to take account of the diagnostic (or not) nature of the C spectrum with respect to environment, i.e., depending on the specific sub-structures. 

Dubois and colleagues studied the problem of overlapping fragments. They developed the program DARC-EPIOS, which can retrieve structural formulas from overlapping C-NMR data [29]. The COMBINE software uses similar techniques. 

DARC-EPIOS is an automated software for retrieving structural formulas from overlapping C-NMR data. 

Automatic Structural Elucidation by C-13 NMR - DARC-EPIOS Method - Search for a Discriminant Chemical Structure Displacement Relationship. 

Many similar methods appear in the literature with different acronyms (e.g., DARC-EPIOS, ACF, three-atom fragments), which have been derived to correlate substructures with the corresponding subspectra. The common idea of all these methods is to describe a larger substructure using an atom-centered topological code and to store this structural information together with the corresponding spectral features. 

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