Dapsone hormonal

Figure 2.6 Dorzolamide 16, a topically active carbonic anhydrase inhibitor, resulted from a structure-based ligand design it is used for the treatment of glaucoma. Sulfaguanidine 17 inhibits thyroid hormone biosynthesis. A phenylog of sulfanilamide 11 (Figure 2.4), dapsone 18, is used for the treatment of leprosy.

Clinically important, potentially hazardous interactions with aluminium hydroxide, antacids, charcoal, cholestyramine, colestimide, colestipol, cyclosporine, cytochrome P4503A substrates, dapsone, estrogenic hormones, nitrendipine, oral contraceptives... 

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