Dantrolene and SCI

Dantrolene (DNT), a long-acting muscle relaxant (Fig. 5.4), acts through ryanodine receptor and abolishes excitation-contraction coupling in muscle cells. Ryanodine-sensitive receptors (RyRs) are involved in the release of intracellular Ca , and this release can be blocked by DNT. Based on electrophysiological studies, it is suggested that injurious effects of Ca in white matter injury may be mediated both 

5 Potential Neuroprotective Strategies for Experimental Spinal Cord Injury 

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