Danazol hepatotoxicity

Danazol is a weak androgen and also has a series of other hormonal and anti-hormonal properties. It inhibits pituitary gonadotropin and has been used in the treatment of endometriosis, fibrocystic disease of the breast, idiopathic thrombocytopenic purpura, and hereditary angioedema. Its hepatotoxic effects include reversible rises in serum transaminases and cholestatic hepatitis a few cases of hepatocellular tumors have been reported. 

It has been suggested that danazol (and the doxycycline) were possibly hepatotoxic, which led to decreased lovastatin metabolism, or that the danazol had a direct toxic effect on the muscles. Efanazol inhibits the cytochrome P450 isoenzyme CYP3A4 by which simvastatin and lovastatin are metabolised, which would result in raised statin levels, and therefore myopathy and rhabdomyolysis. This seems a more likely explanation for the effects seen. 

Liver Hepatotoxic and liver tumor-inducing effects of long-term danazol prophylaxis have been investigated in 92 patients with hereditary angioedema, 46 of whom were taking danazol [34 ]. There were no... 

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See also in sourсe #XX -- [ ]

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