Damage to nucleic acids

Photocycloaddition and photoaddition provide good models for the mechanism by which ultraviolet light can cause damage to nucleic acids. When ultraviolet light damages DNA, the principal reactions occurring involve the nucleic acid bases. Photocycloaddition reactions to form... 

L. and Miranda, M.A. (2000) Tiaprofenic acid-photosensitized damage to nucleic acids a mechanistic study using complementary in vitro approaches. Photochemistry and Photobiology, 71, 499-505. 

Another interesting topic, yet not well understood, is how the oxidation of nucleic acid bases influences the stability of DNA, and in particular, to what extent it changes the nature of intermolecular interactions. The biological consequences of damage to nucleic acids have been the subject of numerous experimental studies [39, 40], DNA may be exposed in vivo to hydroxyl radicals produced during endogenic cellular processes [41,42], Increased concentration of modified nucleic acid base derivatives (i.e., 8-oxo-guanine, 2-oxo-adenine) in cancer cells has been observed. For this reason, the analysis of the influence of modification of nucleic acid bases by hydroxyl radical on the nature of intermolecular interactions seems to be very advisable. The results of calculations presented in Fig. 20.2 show that... 

Molyneux MJ, Davies MJ. 1995. Direct evidence for hydroxyl radical-induced damage to nucleic acids by chromium(VI)-derived species Implications for chromium carcinogenesis. Carcinogenesis 16(4) 875-882. 

Warner WG, Yin J-J, Wei RR. Oxidative damage to nucleic acids photosensitized by titanium dioxide. Free Rad Biol Med 1997 23 851-8. 

In addition, marked oxidative damage to nucleic acids (DNA and RNA) has been reported to occur in PD. Oxidative insults are more pronounced in RNA than DNA because RNA is mostly single stranded and its bases are not protected by hydrogen bonding and specific proteins (Nunomura et al., 2007). As stated above, the oxidative damage to RNA may result in errors in proteins expression or dysregula-tion of gene expression. Studies on analysis of oxidized RNA species have revealed... 

Cadet J, Douki T, Badouard C, Favier A, Ravanat J (2007) Oxidatively generated damage to cellular DNA. In Evans MD, Cooke MS (eds) Oxidative damage to nucleic acids. Landes Bioscience Springer, Austin, pp 1-13... 

---