Daidzein pharmacokinetics

Setchell KD, Faughnan MS, Avades T et al. Comparing the pharmacokinetics of daidzein and genistein with the use of C-labelled tracers in premenopausal women. Am. J. Clin. Nutr. 77,411-419, 2003. 

Knowledge of the pharmacokinetics of isoflavones in soy foods is essential for making recommendations regarding efficacy in clinical studies. Die plasma half-life of daidzein and genistein, measured from their plasma appearance and disappearance curves, is 7.9 h in adults peak concentrations occur 6-8 h after administration of the pure compounds [93] with peak concentrations ranging from 80 to 800 ng/ml (after a single oral dose of 50 mg of pure isoflavones). 

Peng W-X, Li H-D, Zhou H-H. Effect of daidzein on CYPl A2 activity and pharmacokinetics of theophylline in healtiiy volunteers. EurJ Clin Pharmacol (2002) 59, 237-41. 

Nakano H, Ogura K, Takahashi E, Harada T, Nishiyama T, Muro K, Hiratsuka A, Kadota S, Watabe T. Regioselective monosuUation and disulfation of the phytoestrogens daidzein and genistein by human liver sulfotransferases. Drug Metab Pharmacokinet 2004 19 216-226. 

Rufer, C.E., Bub, A., Moseneder, J., Winterhalter, P., Sturtz, M., and Kulling, S.E. 2008. Pharmacokinetics of the soybean isoflavone daidzein in its aglycone and glucoside form a randomized, double-blind, crossover study. Am J Clin Nutr 87, 1314-1323. 

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