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D,L-Sotalol

Eckardt, L., Haverkamp, W., Mertens, H., Johna, R., Clague, J.R., Borggrefe, M., and Breithardt, G., Drug-related torsades de pointes in the isolated rabbit heart comparison of clofilium, d,l-sotalol, and erythromycin, /. Cardiovasc. Pharmacol., 32, 425-434,1998. [Pg.283]

Pacifico, A., et al.. Prevention of implantable-defibrillator shocks by treatment with sotalol. d,l-Sotalol Implantable Cardioverter-Defibrillator Study Group. New Engl J Med, 1999. 340(24) p. 1855-62. [Pg.545]

Blockers are antiarrhythmics of class II according to the Vaughan-Williams classification, effective in the treatment of both supraventricular and ventricular tachyarrhythmias. These drugs can also reduce ectopic beats, especially if they are a result of sympathetic activity. Sotalol is a racemic mixture of the -blocking L-isomer and the class III antiarrhythmic D-isomer. This racemic mixture as well as D-sotalol are used as class Ill-antiarrhythmic. [Pg.308]

Despite the discouraging results of the CAST, post-MI patients with complex ventricular ectopy remain at risk for death. Other drugs besides type Ic drugs have been studied, including sotalol. Sotalol is marketed as a racemic mixture of a D- and L-isomer both are type in potassium blockers, but the L-isomer has /3-blocking actions. Chronic therapy with D-sotalol was studied in patients with remote MI complicated by complex ectopy in the Survival With Oral D-Sotalol (SWORD) trial. Unlike in the CAST, D-sotalol treatment was not designed to cause PVC suppression, yet (as in the CAST) the trial was halted prematurely because of excessive mortality in the treatment arm. Again, the presumed reason for this observation was D-sotalol-related pro arrhythmia. Currently, only two antiarrhythmic... [Pg.342]

Le Garrec L, Delee E, Pascal J-C Direct separation of d- and 1-sotalol mandelate and hydrochloride salts by high performance liquid chromatography. 7. L/. Chromatogr. 1987 10 3015-3023. [Pg.532]

Waldo, A.L. Camm, A.J. de Ruyter, H. Friedman, P.L. MacNiell, D.J. Pauls, J.F. Pitt, B. Pratt, C.M. Schwartz, P.J. Veltri, E.P. Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. Lancet 1996, 348, 7-12. [Pg.198]

In Reference 108, Wang et al. introduced a di- -amyl L-tartrate-boric acid complex for the enantioseparation of propranolol, sotalol, esmolol, atenolol, bisoprolol, metopro-lol, terbutaline, clenbuterol, cycloclenbuterol, bambuterol, and tulobuterol. Uncoated fused-silica capillaries of 50 p,m i.d. with a total length of 53.0cm and an effective length of 45.0 cm were used. A nonaqueous BGE proved useful for the ion-pair formation and the addition of TEA enhanced the enantiomeric discrimination. When a 100-mM boric acid, 80-niM di-n-amyl L-tartrate, 50-mM TEA in MeOH BGE was used, propranolol, sotalol, esmolol, atenolol, bisoprolol, and metoprolol were baseline separated with resolutions ranging from 2.3 (sotalol) to 3.0 (propranolol). Terbutaline, clenbuterol, cycloclenbuterol, bambuterol, and tulobuterol could be baseline separated with resolutions ranging from 3.2 (bambuterol) to 4.2 (clenbuterol) using a 120-mM boric acid, 100-mM di-n-amyl L-tartrate, 50-mM TEA in MeOH BGE. [Pg.1565]


See other pages where D,L-Sotalol is mentioned: [Pg.100]    [Pg.340]    [Pg.100]    [Pg.3170]    [Pg.100]    [Pg.340]    [Pg.100]    [Pg.3170]    [Pg.871]    [Pg.291]    [Pg.89]    [Pg.509]    [Pg.326]    [Pg.158]    [Pg.287]    [Pg.245]    [Pg.1249]    [Pg.642]    [Pg.602]    [Pg.229]    [Pg.1177]    [Pg.1565]    [Pg.106]   
See also in sourсe #XX -- [ Pg.3 , Pg.3 , Pg.32 , Pg.41 ]




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D-Sotalol

L-Sotalol

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