D,L-3-Hydroxy

D,L-3-Hydroxy-N-methyl-morphinan Phenyl trimethyl ammonium chloride D-Tartaric acid... 

The methylation of 51.4 parts by weight of D,L-3-hydroxy-N-methyl-morphinan is carried out with a methylating solution obtained from 51.5 parts by weight of phenyl-trimethyl-ammonium-chloride. The D,L-3-methoxy-N-methyl-morphinan is isolated in the form of its hydrobromide, which melts with 1 mol of water at 92°-94°C, without water at 239°-240°C. The base isolated from the aqueous solution by means of sodium carbonate melts at 81°-83 C. 

The 2,4-dihydroxy-3,3-dimethyl-butironitrile was treated hydrochloric acid and D,L-3-hydroxy-4,4-dimethyl-dihydro-furan-2-one (D,L-pantolacton) was obtained. The racemic mixture of D- and L-pantolactons was a division of D-and L- isomers by the adding of a-phenylethylamine. So D-pantolacton was isolated. 

R,S-thiorphan D.L-4-Mandclic acid D,L-4-bromo-mandelic acid D,L-4-chloro-mandclic acid D,L-3-hydroxy-mandelic acid D,L-4-hydroxy-mandelic acid... 

Lau and Gompf359 prepared a series of 2-amino-6-hydroxybenzo[d]-thiazoles and corresponding naphtho[l,2-d]thiazoles on treating 1,4-benzoquinone and 1,4-naphthoquinone with thiourea in acidic media at room temperature. At high temperature the products of the reaction with 1,4-benzoquinone are 5-hydroxy benz[d]-l,3-oxathiol-2-ones... 

AT-Benzoyl-2-hydroxy-2,3-dihydroindoles (192) are additional products resulting from the photolysis of 2-phenylquinoline 1-oxide (193) and its derivatives in ethanol solution.162 These dihydroindoles are also formed by the solvolysis of the corresponding benz[d]-l,3-oxazepines (194) with aqueous ethanol at room temperature, and are therefore interpreted as arising in this way in the photolysis. Quinoline 1-oxide itself undergoes ring contraction166 to IV-formyl-2-hydroxy-2,3-dihydroindole on irradiation in a protonic solvent. 

AC Dahl, Jo Madsen. Baker s yeast production of D- and L-3-hydroxy esters. Tetrahedron Asymmetry 9 4395-4417, 1998. 

Tetrafluoroboric acid-diethyl ether complex (catalytic amount) was added to a stirred solution of epoxide (+/-)-(3aa,6a,7a,7aa)-6,7-epoxy-3a,6,7,7a-tetrahydrobenzo[d]-l,3-dioxol-2-one (32 mg, 0.2 mmol) and (R)-(+)-sec-phenethyl alcohol (0.048 ml, 0.4 mmol) in DCM at RT under argon. After 30 min, water was added and the mixture extracted with DCM (3 times). The combined organic phase was dried (MgS04) and evaporated in vacuum. Column chromatography (30-75% ether-petrol, gradient elution) of the residue afforded the alcohols [3aR-[3aa,4a,5p(R),7aa]-3a,4,5,7a-tetrahydro-4-hydroxy-5-(l-phenylethoxy)benzo[d]-l,3-dioxol-2-one and [3aS-[3aa,4a,5P(R),7aa]-3a,4,5,7a-tetrahydro-4-hydroxy-5-(l-phenylethoxy)benzo[d]-l,3-dioxol-2-one. (37 mg, 67%) as a thick oil and a 1 1 mixture of diastereomers. Subsequent HIPLC (l -Dynamax 83,123-6 column 6% isopropanol-petrol, 15 ml/min) effected separation of the diastereomers. Less polar [3aR-[3aa,4a,5p(R),7aa]-3a,4,5,7a-tetrahydro-4-hydroxy-5-(l-phenylethoxy)benzo[d]-l,3-dioxol-2-one had retention time 16.3 min [a]D2° +90.1° (c 1.1, CHCI3). 

Dimethyl-l-(phenyl-acetyl)- E8b, 432 (2,4-Pentandion + Ar — CH2-CO-NH-NH2) Pyrido 4,3-d -l,3-oxazol 6-Methyl-2-phenyl-4,5,6,7-tetrahydro- E8a, Pyrimidine 4-Hydroxy-S-isopropyl-2-phenyl- E9b/2, 100 (R-CH = CH-NR2 + Ar-CO-NCO)... 

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