D-Glucosiduronic acids

IC with bovine enzyme which is very similar to the human one. Inhibitor concentration for 50% inhibition. K of substrate (phenyl a-D-mannopyranoside). K of substrate (4-nitrophenyl a-D-manno-pyranoside). K of substrate (4-nitrophenyl D-glucosiduronic acid). K of substrate (4-nitrophenyl 2-acetamido-2-deoxy- o-glueoside). Inhibitors were chitotetraono-1,5-lactone and chitotetraose, respectively. 

Tri-O-methyl-D-glucose-(4— 1) 2,3,4-tri-O-methyl-D-glucosiduronic acid Pneumococcus Type III specific polysaccharide B 0 64a... 

D-Xylose-(2 —> 1) 4-O-methyl-D-glucosiduronic acid Aspen wood A a 67 See 70d, 70e... 

Methyl a-D-galactoside)-(6 —> 1) 4-0-methyl-/3-D-glucosiduronic acid, amide (Methyl 2,3,4-tri-O-methyl-a-D-galactoside)- 267 + 25 h2o 13, 56... 

Garton, Robinson and Williams66 have studied the rate of acid hydrolysis of phenyl D-glucosiduronic acid as compared with phenyl acid sulfate. The ester acid sulfate was hydrolyzed completely by N hydrochloric acid at 93-95° in 10 minutes, 50 times as rapidly as the D-glucosiduronic acid. After 20 minutes, only 40% of the latter was hydrolyzed. On refluxing... 

Hydrolysis of the xylenyl D-glucosiduronic acids by 5N sulfuric acid for 1.5 hours in a boiling water bath results in a variable loss of D-glucuronic acid.67... 

IV. d-Glucosiduronic Acids of Compounds Having Reduced Rings ... 

Perhydroxylation.—A metabolic reaction beginning to take an aspect of major importance is the partial ring reduction and dihydroxy substitution termed perhydroxylation. The relevant data have recently been summarized in a symposium.117 This reaction was first shown to occur with anthracene by Boyland and Levi,118 who also found that the product formed, in the rabbit, is a D-glucuronic conjugate, l,2-dihydro-l,2-dihy-droxyanthracene D-glucosiduronic acid (VIII). Apparently, an isomer is... 

---