D,/-Camphor

Using 28% acetic acid allows the eugenol, d-camphor and pinene to form its own top layer. There ivas no separation using 99.5% acetic acid. 

The present method is adapted from that of Loven. The resolution has been carried out with d-a-bromocamphor-TT-sulfonic acid (f-form) 2.3 with /-and d/-malic acids (d- and /-forms) with /-quinic acid and d-tartaric acid (d- and /-forms) and with d- and /-6,6 -dinitrodiphenic acids (d- and /-forms). Methods employing d-benzyimethylacetyl chloride, d-oxymeth-ylenecamphor, /-quinic acid, and d-camphoric anhydride are of theoretical interest only. The d/-amine is not resolved by the active camphor-lo-sulfonic acids or mandelic acids. ... 

Rabak detected d-camphor, ciuwjl, piueiie, ihev oce. and horneol io tbe oil, as well as Icaces of free Coi niic acid, and loimic j.od acclic acids in the form ot esters. 

C H, i04 124-83-4) see Carnitine Dexfenfluramine (lfi,35)-(-l-)-camphoric acid see under D-camphoric acid camptothecin... 

C7H iBrN207 77-65-6) see Acecarbromal L-carnitinamide D-camphorate (Ci7H32N20(j 73804-72-5) see Carnitine DL-carnitinamide chloride... 

Because both enantiomers, (+) and (-)-camphoric add, are available by oxidation either from natural (+)-D-camphor or from natural (-)-L-borneol, both enantiomers of camphanoyl chloride can be prepared conveniently.3 5 The corresponding enantiomers of camphanic acid were described for the first time by Wreden6and Aschan.7 The three-step procedure, described above is an adaptation of procedures described by Aschan,8 Zelinsky et al.,9 Meyer et al.,10 and Gerlach.3... 

Weizmann, A. Occurrence of d-camphor in an Israeli Artemisia species. Res. 

Equilibrium studies have shown that the first formation constant of the chromium(iii)-ethylenediamine system is < 10, over 10 -fold smaller than the value (10 ) previously reported. [Cr(en)3 (tn) ] (x = 0—3 and tn = tri-methylenediamine) complexes have been prepared and resolved using nitro-(-f )D-camphor. These mixed complexes have the same absolute configuration, A, as the pure [Cr(en)3] and [Cr(tn)3] species. Selective intervention of an optically active counterion in the relaxation processes of excited enantiomeric complexes can lead to partial resolution. This has been achieved for [Cr(phen)3] using D-tartrate. ... 

Leuschner J Reproductive toxicity studies of D-camphor in rats and rabbits. Arzneimit-telforschung 47(2) 124—8,1997... 

D-Camphor-lO-sulfonic acid (CSA) has been utilized to form aj-fused bicyclic acetals from hexopyranosides (Scheme 20) <1997TL849>. A silver terrafluoroborate-promoted cyclization of a series of 3-hydroxyalkyl-2-cyanopiperidines has been used to prepare the octahydropyrano[2,3- ]pyridine of upenamide (Scheme 21) <2004EJ01057>. Related pyranopyr-idines have been prepared using an intramolecular Wadsworth-Emmons cyclization <2003TL8545>. 

Derivatization of chiral arylalkylamines and NMR measurement of the diastereomeric ratios can be conveniently performed using d-camphor-10-sulfonic acid, having the (l/ ,4/ ) configuration49. 

Asymmetric alkylation of benzylamine via the imine 6A, with ( + )-D-camphor (5 A) as chiral auxiliary is possible. Deprotonation with butyllithium and subsequent alkylation with haloalkanes, (R X) afforded the alkylated imines 7 A with reasonable yield but variable diastereo-selectivity. The diastereoselectivity depends strongly on the haloalkane with methoxy-substi-tuted halomethylbenzenes moderate to good diastereoselectivity (d.r. 80 20-90 10) is obtained, however, with haloalkanes or 3-halopropenes only low optical purities (< 50%) were observed. 

Resolution of Triethylenediamino-chromic Iodide.—Triethyl-enediamino-chromic chloride in aqueous solution was mixed with sodium d-camphor nitronate, when the sparingly soluble d-triethylcnecli-... 

Triethylenediamino - chromic Iodide, [Cr en3]I3.H20, is obtained from the mother-liquor from the action of sodium d-camphor nitronate and racemic triethylenediamino-chromic chloride by adding sodium iodide, filtering off the precipitate of inactive [Cr en3]I3 formed, and adding solid sodium iodide to the filtrate when the 1-niodification separates. In appearance it resembles the d-salt, and has rotation ... 

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