D-a-Amino-4-hydroxyphenyl acetic

The amino group of compound 412 (R = Me) was reacted first with N, O-bis(trimethylsily)acetamide in boiling acetonitrile, then with D-a-amino(4-hydroxyphenyl)acetic acid in tetrahydrofuran or with phosgene in tetrahy-... 

Sodium N-(l-methoxycarbonyl-l-propen-2-yl)-D(-)-a-amino-(4-hydroxyphenyl)acetate Ethyl chlorocarbonate... 

The majority of the semisynthetic cephalosporins are not effective when administered orally. The main exceptions are cephalexin and cephradine, and recently reported compounds such as cefaclor, cefadroxyl and cefatrizine. In view of the fact that oral activity is observed primarily in derivatives of a-amino aryl acetic acids, we designed our synthetic course on the basis of modification of the aryl part of a readily available a-amino acid, in such a way that initial functionalization of the aromatic ring would provide a "handle , which could in turn be easily converted into a variety of functional groups. The second in5)ortant criterion was the necessary optical activity of the amino acids. In order to avoid the resolution of each individual compound thus obtained, it was deemed important to start with an optically active amino acid whose modification would proceed without racemization. These two requirements were fulfilled upon chloromethylation of D-a-amino-4-hydroxyphenyl acetic acid 1. ... 

D-(— )-a-amino-a-(4-hydroxyphenyl)acetamido]-3-methyl-3-cephem-4-carbojQ lic acid (6i ,7i )-7-[(fi)-2-amino-2-(p-hydroxyphenyl) acet imido]-8-oxo-3-propenyl-5-thia-l-azabicyclo[4.2.0]oct-2-ene-2-carbo3Qrlic acid... 

C15H21NO5) see Gusperimus trihydrochloride 4-[hydroxy[5-[[(phenylmethoxy)carhonyl]amino]pen-tyl]amino]-4-oxobutanoic acid (C,7H24N20ft 106410-46-2) see Deferoxamine D-a-(4-hydroxyphenyl)-tx-(2-methoxycarbonyl-l-methyl-cthenylamino)acetic acid anhydride with monoethyl carbonate... 

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