Cytochromes structure-function relationships

Szklarz GD, Halpert JR. Use of homology modeling in conjunction with site-directed mutagenesis for analysis of structure-function relationships of mammalian cytochromes P450. Life Sci 1997 61 2507-20. 

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De Smet L, Sawides SN, Van Horen E et al (2006) Structural and mutagenesis studies on the cytochrome c peroxidase from Rhodobacter capsulatus provide new insights into structure-function relationships of bacterial di-heme peroxidases. J Biol Chem 281 4371 1379... 

There are several types of nitrite reduetion reaetion in biology and the use of the eommon name initrite reductasei for the enzymes eatalysing these reactions causes endless confusion. Thus we begin this article by outlining the different types and functions of the nitrite reductases before focusing on the structure/function relationships for one type of enzyme, cytochrome cdi nitrite reductase. 

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Halkier, B.A. (1996) Catalytic reactivities and structure/function relationships of cytochrome P450 enzymes. Phytochemistry, 43,1-21. 

AIMD has been used extensively to elucidate structure/function relationships in myoglobin and cytochromes. 

Metal Ions in Biological Systems Exploring Structure-Function Relationships in Yeast Cytochrome c Peroxidase Using Mutagenesis and Crystallography , Sigel,... 

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Three-dimensional structural studies on C4H, C3H , and F5H have not yet been reported, partiy because plant cytochrome P-450 structural studies in general have lagged significantly behind their mammalian and bacterial counterparts. Accordingly, much of our current understanding on catalysis and structure-function relationships of plant P-450s is derived from structural studies with bacterial/mammalian homologs. ... 

Wang, H., R. Dick, H. Yin, E. Licad-Coles, D. Kroetz, G. Szklarz et al. (1998). Structure-function relationships of human liver cytochromes P450 3A Aflatoxin B1 metabolism as a probe. Biochemistry 37, 12536-12545. 

Structure-Function Relationships in Cytochrome c Oxidase and Other Hemeproteins... 

In early studies of cytochromes, spectroscopic methods were relied upon for determination of spin state, coordination number, and axial-heme ligation. Model hemes in which metal-ion size, charge, and d-orbital occupancy, as well as ligand structure and composition, could be systematically varied, were spectrally characterized for comparison to cytochromes. Synthetic 6cLS Fe and Fe porphyrinates have been studied for many years with the goal of clarifying structure-function relationships observed in cytochromes. 

Shimada T, Tanaka K, Takenaka S, Murayama N, Martin MV, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M (2010) Structure-function relationships of inhibition of human cytochromes P450 lAl, 1A2, IBl, 2C9, and 3A4 by 33 flavonoid derivatives. Chem Res Toxicol 23 1921-1935... 

Conjunction with Site-Directed Mutagenesis For Analysis of Structure-Function Relationships of Mammalian Cytochromes P450. 

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