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Cytochromes endogenous substrates

All cytochrome P450s are hemoproteins and generally have a wide substrate specificity, acting on many exogenous and endogenous substrates. They represent the most versatile biocatalyst known. [Pg.632]

Both xenobiotics and endogenous substrates are primarily metabolized by a super-family of enzymes, named cytochrome F450s (CYP450s,... [Pg.424]

West. S.B. and Lu, A.Y. (1972) Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. V. Competition between cytochromes P-450 and P-448 for reductase in 3,4-benzpyrene hydro-xylation. Archives of Biochemistry and Biophysics, 153, 298-303. [Pg.192]

The possibility that the second electron is derived from NADH through cytochrome bs has been the subject of argument for some time and has yet to be completely resolved. Cytochrome bs is a widely distributed microsomal heme protein that is involved in metabolic reactions such as fatty acid desaturation that involve endogenous substrates. It is clear, however, that cytochrome bs is not essential for all... [Pg.115]

Lake BG, Tredger JM, Gray TJ, et al. 1984c. The effect of peroxisome proliferators on the metabolism and spectral interaction of endogenous substrates of cytochrome P-450 in rat hepatic microsomes. Life Sci 35 2621-2626. [Pg.275]

Cytochrome 6-556 is fully reduced by succinate in both coupled and uncoupled mitochondria. It is partially reduced by endogenous substrate in the presence of antimycin, thus differing from type c cytochrome as assumed by earlier workers 273,274). The a band of cytochrome 6-556... [Pg.590]

Kupfer, D. (1982). Endogenous substrates of monooxygenases Fatty acids and prostaglandins. In J.B. Schenkman and D. Kupfer (eds). Hepatic Cytochrome P450 Monooxygenase System. Pergamon Press, Elmsford, NY, pp. 157-190. [Pg.320]

Putative cytochrome 450-catalyzed MFO activities have been identified or indicated towards a number of endogenous substrates, viz. steroid 17a-hydroxylase... [Pg.91]

Cheng Q, Guengerich FP (2013) Identification of endogenous substrates of orphan cytochrome P450 enzymes through the use of untargeted metabolo-mics approaches. Methods Mol Biol 987 71-77... [Pg.380]

Tang Z, Martin MV, Guengerich FP (2009) Elucidation of functions of human cytochrome P450 enzymes identification of endogenous substrates... [Pg.700]

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See also in sourсe #XX -- [ Pg.62 , Pg.63 , Pg.64 , Pg.65 , Pg.66 , Pg.67 , Pg.68 , Pg.69 ]



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