Cytochrome P450 structural features

Another important and highly conserved feature in all structures of cytochromes P450 with only a few exceptions is the... 

The two-domain, structural motif in FNR represents a common structural feature in a large class of enzymes that catalyze electron transfer between a nicotinamide dinucleotide molecule and a one-electron carrier. Beside the photosynthetic electron-transfer enzyme, others non-photosynthetic ones include flavodoxin reductase, sulfite reductase, nitrate reductase, cytochrome reductase, and NADPH-cyto-chrome P450 reductase. FNR belongs to the group of so-called dehydrogenases-electron transferases, i.e., flavoproteins that catalyze electron transfer from two, one-electron donor molecules to a single two-electron acceptor molecule. 

Black, S.D. and M.J. Coon (1982). Structural features of liver microsomal NADPH-cytochrome P450 reductase hydrophobic domain, hydrophilic domain and connecting region. J. Biol. Chem. 257, 5929-5938. 

A broad review of the pharmacokinetic basis for H2 antagonlst drug interactions Includes a discussion of structural features present in clmetldine, but not ranitidine, that contribute to binding to the cytochrome P450 linked mixed function oxidase. ... 

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