Cytochrome P450 nomenclature

Nelson DR. 1998. Cytochrome P450 nomenclature. Methods Mol Biol 107 15-24. 

D. Nelson, Cytochrome P450 nomenclature, in 1. Phillips, E. Shephard (Eds.), Cytochrome P450 protocols, vol. 320, Humana Press, New York, USA, 2006, pp. 1-10. 

Human Cytochrome P450 CYP) Allele Nomenclature Committee home page. Available at www.imm.ki.se/CYPalleles/cyp2d6.htm. 

Ingelman-Sundberg, M., A.K. Daly, M. Oscarson, and D.W. Nebert, Human cytochrome P450 (CYP) genes recommendations for the nomenclature of alleles. Pharmacogenetics, 2000.10(1) 91-3. 

The cytochrome P450 system is the principal enzyme system for the metabolism of lipophilic xenobiotics. It is a heme-containing, membrane-bound, multi-enzyme system which is present in many tissues in vivo but is present at the highest level in liver. A coenzyme, cytochrome P450 NADPH oxidoreductase (OR), is essential for P450 catalytic function and cytochrome bs may stimulate catalytic activities of some enzymes. In human liver, it is estimated that there are 15-20 different xenobiotic-metabolizing cytochrome P450 forms. A standard nomenclature, based on relatedness of the amino acid sequences, has been developed (Nelson et al., 1993). The most recent... 

Figure 9.1. Nomenclature of cytochromes P450. Members of the same family share >40% amino acid homology, and members of the same subfamily share >55% amino acid homology.

Source Nelson, D. R., et al. Comparison of cytochrome P450 genes from the mouse and human genomes including nomenclature recommendations for genes, pseudogenes, and alternative-splice variants. Pharmacogenetics 14, 1-18, 2004. 

Home Page of the Human Cytochrome P450 (CYP) Allele Nomenclature Committee. . 2006. 

From Human Cytochrome P450 (CYP) Ailele Nomenclature Committee. CYP allele nomenclature. http //www.imm.ld.se/CYPalleles (Accessed December 5, 2004). Reproduced witli the permission of Sarah C. Sim, Webmaster. ... 

Sim SC, Ingelman-Sundberg M (2010) The human cytochrome P450 (CYP) allele nomenclature website a peer-reviewed database of CYP variants and their associated effects. Hum Genomics 4 278-281... 

Fig. 5. Nomenclature system for designating enzymes and alleles of cytochrome P450. From Linder MW, Valdes R Jr. Pharmacogenetics fundamentals and applications. Therapeutic drug monitoring and toxicology. AACC 1999 20(l) 11 with permission.)...

Allele nomenclature for Cytochrome P450 enzymes. Available at http //www.cypalleles. ki.se. 2008. Accessed March 28, 2008. 

Allelic variants for other CYP isoforms involved in the metabolism of drugs have been documented and in some cases effects of allelic variants have been examined. A compendium of allelic variants for human CYP isoforms in families 1, 2, 3, and 4 is available on the Web at the home page of the Human Cytochrome P450 (CYP) Allele Nomenclature Committee (http //www.cypaheles.ki.se/cypalleles.html). 

Human cytochrome P450 (GYP) nomenclature committee web http //www.imm.hi.se/cypaUeles/ [last accessed September 4, 2004]... 

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