Cytochrome P450 enzymes locations

Figure 3.7 Biosynthesis of cyanogenic glucosides. The biosynthetic pathway of cyanogenic glucosides exemplarily is mentioned for dhurrin. The biosynthesis is performed by the two multi-functional cytochrome P450 enzymes and a UDP-glucosyltransferase. All three enzymes are joined together in a metabolon located in the ER-membrane (according to Nielsen et al., 2008).

PCBs as well as many other xenobiotics are substrates of enzymes found in liver cells. Like other biotransformation enzymes, the monooxygenase enzyme system cytochrome P450 is located... 

Fig. 21.4 Three-dimensional structure of the enzyme cytochrome P450 oxidoreductase. The cofactors FAD and FMN are depicted in light blue. Loop regions are represented by cylindrical rods (yellow) a-helices and /(-sheets (in white) are represented by ribbons and arrows, respectively. Resonance assignments for the residues located in the key loops regions [30] highlighted in purple and red were obtained with a 3D SEA-HNCA-TROSY experiment.

The first stage 1 reaction i.e. oxidation-reduction are generated by a common hydroxy-lating enzyme system (cytochrome P450 system CYP), which is located in... 

Endoplasmic reticulum (ER) May be divided into rough ER with attendant ribosomes involved with protein synthesis and smooth ER where cytochrome P450 and many other drug-metabolizing enzymes are located. 

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