Cytochrome P450 enzymes intermediate metabolizers

Animal studies suggest that furan is readily absorbed via all routes of exposure. Furan is oxidized by the cytochrome P450 enzymes in the liver and other tissues and may form epoxide intermediates however, the precise intermediates have not yet been identified. Intermediates of furan may include enedials and dialdehydes, which are metabolized to CO2 and eliminated through the lungs. Examination of urinary output following furan administration in animals revealed a complex mixture of mercapturate metabolites of furan. 

Pathophysiology Acetaminophen is metabolized via the cytochrome P450 enzymes into a deleterious product A-acetyl benzoquinoneimine, an unstable intermediate, which causes arylated derivatives of protein, lipid, ribonucleic acid (RNA), and deoxyribonucleic acid (DNA), causing destruction of these compounds. Because the Uver has high levels of cytochrome P450 enzymes, it is the major organ affected by acetaminophen overdose. 

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