Cytochrome P450 classification

Kless, A., Eitrich, T. Cytochrome P450 classification of drugs with support vector machines implementing the nearest point algorithm, Lect. Notes Comput. Sci. 2004, 3303,191-205. 

SuSNOW, R.G. and Dixon, S.L. Use of robust classification techniques for the prediction of human cytochrome P450 2D6 inhibition. J. Chem. Inf. Comput. 

Yamashita, F., Hara, H., Ito, T., Hashida, M. Novel hierarchical classification and visualization method for multiobjective optimization of drug properties application to structure-activity relationship analysis of cytochrome P450 metabolism. J. Chem. Inf. Model. 2008, 48, 364-9. 

Classification and Evolution of Cytochrome P450. The techniques of molecular... 

TABLE 9.5. Classification of Human Cytochrome P450s Based on Major Substrate Class... 

Figure 13.2. A proposal for a simplified classification of CYPs with reference to either use of a ferredoxin or alternative electron transport mechanism. Class la— typical bacterial system supported by ferredoxin and ferredoxin reductase, for example, CYPlOl Class Ib—Rhodococcus sp. CYP fusion protein containing a ferredoxin domain Class Ic—Methylococcus capsulatus CYPS 1-ferredoxin fusion . Class 11a— typical eukaryotic CYP/NADPH-cytochrome P450 reductase system Class lib—a fusion protein of a CYP and flavoprotein reductase, for example, P450gM 3 Class IIc—P450 j containing separate flavodoxin and flavodoxin reductase partners . Class fll—standalone functional CYPs, for example, P450jj. ...

Hasegawa K, Funatsu K. Bayesian classification of cytochrome P450 3A4 substrates/non-substrates and color mapping for chemical interpretation. J Comput Aided Chem 2010 11 19-24. 

Moktali V, Park J, Fedorova-Abrams ND, Park B, Choi J, Lee Y-H, Kang S (2012) Systematic and searchable classification of cytochrome P450 proteins encoded by fungal and oomycete genomes. BMC Genomics 13 525... 

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