CYP Cytochromes

Second- and Third-Generation Antidepressants and Cytochrome (CYP) P450 Enzyme Inhibitory Potential... 

Table 9.1 Selected listing of important web sites regarding cytochrome CYP metabolism/substrates.

Fluoxetine and paroxetine inhibit cytochrome CYP P-450 2D6 and thus may affect metabolism of some opioids, e.g. codeine, 0) codone and tramadol, that are partly metabolised by CYP2D6, many antipsychotic drugs and tricyclic antidepressants. 

Sidhu JS, Omiecinski CJ. Modulation of xenobiotic-inducible cytochrome CYP gene expression by dexamethasone in primary rat hepatocytes. Pharmacogenetics 1995 5 24-36. 

After modification of lead compound 12, it was found that pyrimidines containing the 3-methylindazole heterocycle and methylated at the C-4 amino nitrogen possessed both good in vitro and cross-species pharmacokinetic profiles. The replacement of the 3,4,5-trimethoxy aniline with a 3-aminobenzenesulfonamide led to comparable potencies. However, significant inhibition (/C50 < 10 pM) was observed against a number of cytochrome (CYP) P450 isozymes, presumably resulting from... 

Pretreatment with cytochrome (CYP) inducers such as phenobarbital enhances the rate of activation of the azoxyphosphorenes but does not alter total exposure to active metabolites over time and does not affect toxicity or efficacy. Cyclophosphamide is eliminated by hepatic metabolism and can be used at full doses in patients with renal insufficiency. Maximal concentrations in plasma are achieved 1 hour after oral administration the tj of parent drug in plasma is -7 hours. 

Bieche I, Naijoz C, Asselah T, Vacher S, Marcellin P, Lidereau R, Beaune R de Waziers I (2007) Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)l, CYP2 and CYP3 families in 22 different human tissues. Pharmaco-genet Genomics 17 731-742... 

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