Synthesis cysteine conjugates

Free form Glycosidic precursors Cysteine conjugates Other precursors De novo synthesis Release / modification... 

Bernkop-Schnurch, A., Brandt, U.M., and Clausen, A.E. (1999) Synthesis and in vitro evaluation of chitosan-cysteine conjugates Sci. Pharm. 67 196-206. 

In a similar reaction, chlorinated thiophenols were added to a-acetamldoacryllc acid for the synthesis of mercapturlc acids of polychlorinated benzenes (196). This method produces a DL-mlxture of the N-acetyl-cystelne conjugate and It Is limited to the synthesis of mercapturlc acids and cysteine conjugates, the latter obtained after deacetylation. 

The reversibility of the Smiles rearrangement (Figure 11) may occasionally be of use for synthesis of cysteine conjugates (202). The S-M reaction Is known to occur rapidly under both alkaline and neutral conditions In DMF and DMSO and therefore It must be considered as a possible source of rearrengement products during the Isolation of cysteine conjugates Involving the use of these solvents. 

Addition reactions, synthesis of glutathione, cysteine, and -acetyl-cysteine conjugates, 142... 

Greiner, D.P., Miyake, R., Moran, J.K., Jones, A.D., Negishi, T., Ishihama, A., and Meares, C.F. (1997) Synthesis of the protein cutting reagent iron (S)-l-(p-bromoacetamidobenzyl)ethylenediaminetetraacet ate and conjugation to cysteine side chains. Bioconjugate Chem. 8(1), 44-48. 

Scheme 13. Conjugate addition of cysteine thiol group to the maleiimido functionality for the synthesis of protein-peptide constructs...

Elfarra, A.A., Sharer, J.E. Duescher, R.J. (1995) Synthesis and characterization of Wacetyl-L-cysteine S-conjugates of butadiene monoxide and their detection and quantitation in urine of rats and mice given butadiene monoxide. Chem. Res. Toxicol.. 8, 68-76... 

The CM of fatty acids and derived compounds also has been used for the production of fine chemicals that are difficult to obtain by other synthetic approaches. Some examples include the synthesis of a plant growth stimulant, an insect pheromone precursor, the sex pheromone of the peach twig borer moth, and others [28]. Furthermore, the conjugation of fatty acid derivatives, sugars, and amino acids via CM was shown by Vemall and Abell [41]. C4 with a catalyst loading of 20 mol% was used to perform the CM of either Ai-Boc-L-ly sine or N-Boc-L-cysteine bearing a 10-undecenoic chain with methyl 10-undecenoate or a sugar olefin. 

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