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CYP2D6 enzyme 322 INDEX

Drug-Drug and Drug-Food Interactions. Since cinacalcet is metabolized by multiple hepatic enzymes there is potential for drug interactions. Cinacalcet is also a potent inhibitor of the enzyme CYP2D6. As a result, dose adjustments of concomitant medications that are predominantly metabolized by this enzyme and have a narrow therapeutic index such as flecainide, thioridazine, vinblastine, and most tricyclic antidepressants (i.e., amitriptyline) may be required. ... [Pg.840]

Although studies in vitro did not reveal an inhibitory effect of escitalopram on CYP2D6, limited in vivo data with desipramine , (p.l241) and metoprolol , (p.855) suggest a modest inhibitory effect. The UK manufacturer recommends caution if escitalopram is given with drugs that are mainly metabolised by this enzyme, and that have a narrow therapeutic index. They specifically name fleeainide. ... [Pg.260]

See other pages where CYP2D6 enzyme 322 INDEX is mentioned: [Pg.149]    [Pg.190]    [Pg.234]    [Pg.215]    [Pg.53]    [Pg.177]    [Pg.78]    [Pg.20]    [Pg.222]    [Pg.514]    [Pg.837]    [Pg.491]    [Pg.55]    [Pg.366]   


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CYP2D6 enzyme

Enzymes 658 / INDEX

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