CYP2C9 gene polymorphisms

Schwarz UI. Clinical relevance of genetic polymorphisms in the human CYP2C9 gene. Eur J Clin Invest 2003 33(suppl 2) 23-30. 

Schwarz UI (2003) Clinical relevance of genetic polymorphisms in the human CYP2C9 gene. Eur J Clin Invest 33 23-30 Scordo MG, Aklilln E, Dahl ML et al. (2001) Genetic polymorphism of cytochrom P450 2C9 in a Caucasian... 

The CYP2C9 gene is adjacent to that of CYP2C19 and is also polymorphic. CYP2C9 is also involved in drug metabolism of relevance to medicine... 

H. Ninomiya, N. Tashiro et al. (2001). Genetic polymorphisms and functional characterization of the 5 -flanking region of the human CYP2C9 gene In vitro and in vivo studies. Clin. Pharmacol Then 70, 175-182. 

Gaikwad T, Ghosh K, Kulkami B, Kulkaml V, Ross C, Shetty S. Influence of CYP2C9 and VKORCl gene polymorphisms on warfarin dosage, over anticoagulation and other adverse outcomes in Indian population. Eur J Pharmacol 2013 710(l) 80-4. 

Some enzymes—notably CYP2C9 and CYP2C19—are encoded by genes which contain polymorphisms that alter structure and catalytic function of the enzyme rather than altering the level of expression for 2C9 and 2C19 the range of catalytic variation in vivo is determined much more by the polymorphisms that alter enzyme structure than by the genetic and environmental factors that alter expression levels of the enzyme. 

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