Cyclothiazide

Preparation of the aldehyde required for the synthesis of cyclothiazide (182) starts by carbonation of the Grignard reagent obtained from the Diels-Alder adduct (186) from allyl bromide and cyclopentadiene.The resulting acid (187) is then converted to the aldehyde (189) by reduction of the corresponding diethyl amide (188) with a metal hydride. 

Cycle pent hi azide 1, 368 Cyclophosphamide 3, 161 Cycl opryazate 1, 5 2 Cycloserine 14 Cyclothiazide 358 Cycrimine U 47 Cyheptamide 222 Cypenamine 2, 7 Cyprazepam 7, 402 Cyproheptadine 161... 

Endomethylene-A -tetrahydro benzaldehyde Cyclothiazide Epibromohydrin Carteolol Epichlorohydrin Acebutolol Atenolol Befunolol Betaxolol HCI Bufetrol Bunitrolol Bupranolol Carazolol Carnitine Celiprolol Colestipol Cromolyn sodium I ndenolol Mazindol Mepindolol Metoprolol tartrate Nadolol Nifuratel Oxprenolol Penbutolol Practolol Propafenone HCI Propranolol HCI Viloxazine HCI Xanthinol niacinate Epinephrine... 

In this context, the enantiomeric pair containing the eutomer of cyclothiazide can be resolved by HPLC on cellulose-derived coated CSPs. Nevertheless, the poor solubility of this compound in solvents compatible with this type of support makes this separation difficult at preparative scale. This operation was achieved with a cellulose carbamate fixed on allylsilica gel using a mixture of toluene/acetone as a mobile phase [59]. 

CiH40 107-02-8) see Abacavir Chlorthenoxazine Cyclothiazide Letosteine Oxitriptan Teibinafine L-Tryptophan acrylic acid... 

Antihistamines Pharmaceutical tablets, 2.1 pmol (cyclothiazide) 9 pmol (brompheniramine)... 

AMPA receptors desensitize within milliseconds upon exposure to AMPA, and kainate receptors likewise upon exposure to kainate. AMPA and kainate receptors can be securely distinguished from one another by their response to two drugs, cyclothiazide and the lectin concanavalin A [10], Cyclothiazide relieves AMPA receptor desensitization without affecting kainate receptors. 

An important class of noncompetitive antagonists selective for AMPA receptors is represented by the 2,3-benzodiazepines such as GYKI 53655. These compounds act at sites different from those acted on by cyclothiazide and are useful tools for isolating synaptic responses mediated by kainate receptors. These compounds also show some promise as neuroprotective drugs for treating ischemic neuronal injury. 

The first allosteric modulators discovered to act on AMPA/KA receptors were the plant lectins, including concanavalin A (ConA), that block receptor desensitization, probably through binding to Y-1 inked oligosaccharides (51,52). It was soon discovered that certain benzothiazides, such as diazoxide and cyclothiazide, also act on the same allosteric site controlling non-NMDA receptor desensitization (53-55). Interestingly, ConA and cyclothiazide show high selectivity for KA and AMPA receptors, respec-... 

Wong, L. A. and Mayer, M. L. (1993) Differential modulation by cyclothiazide and con-canavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepro-pionic. Mol. Pharmacol. 44, 504-510. 

Patneau, D. K., Vyklicky, L., Jr., and Mayer, M. L. (1993) Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate. J. Neurosci. 13,3496-3509. 

Cyclopropylmethyl bromide, physical properties of, 4 350t Cyclosilicates, 22 453t Cyclosiloxanes, polymerization of, 14 259 Cyclotetramethylenetetranitramine, 10 735-736 Cyclothiazide, 5 168 Cyclotrimethylenetrinitr amine, 10 735 17 160... 

A few important drugs, namely thiazide diuretics (e.g., chlorothiazide, hydroflumethiazide, bendroflumethiazide, benzthiazide, cyclothiazide etc.), neomycin, tetracyclines, methyldopa etc., help in enhancing the BUN levels perhaps due to interference with normal renal function,... 

Thiazide diuretics (benzothiadia-zines) include hydrochlorothiazide, benzthiazide, trichlormethiazide, and cyclothiazide. A long-acting analogue is chlorthalidone. These drugs affect the intermediate segment of the distal tubules, where they inhibit a Na+/Ch cotransport, Thus, reabsorption of NaQ and water is inhibited. Renal excretion of Ca decreases, that of Mg + increases. Indications are hypertension, cardiac failure, and mobilization of edema. 

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