Epinephrine cyclopropane

Morris LE, Noltensmeyer MH, White JM Jr. 1953. Epinephrine induced cardiac irregularities in the dog during anesthesia with trichloroethylene, cyclopropane, ethyl chloride and chloroform. Anesthesiology 14 153-158. 

Cyclopropane increases the irritability of the heart by acting on its autonomic tissue and has a tendency to induce irregularities that may terminate in fatal fibrillation. The use of epinephrine is contraindicated in cyclopropane anesthesia because this drug tends to induce ventricular fibrillation (see Table 16). 

A. An enhanced arrhythmogenic effect may occur when epinephrine is given to patients with chloral hydrate overdose or anesthetized with cyclopropane or halogenated general anesthetics. 

Patients anaesthetised with inhalational anaesthetics (particularly cyclopropane and halothane, and to a lesser extent desflurane, enflurane, ether, isoflurane, methoxyflurane, and sevoflurane) can develop cardiac arrhythmias if they are given adrenaline (epinephrine) or noradrenaline (norepinephrine), unless the dosages are very low. Children appear to be less susceptible to this interaction. file addition of adrenaline to intrathecal tetracaine enhances the sedative effects of propofol. 

Katz RL, Matteo RS, Rapper EM. The injection of epinephrine during general anesthesia with halogenated hydrocarbons and cyclopropane in man. 2. Halothane. Anesthesiology (1962) 23, 597-600,... 

---