Ranitidine Cyclophosphamide

Clinically important, potentially hazardous interactions with aluminum, aminophylline, aspirin, chlorambucil, cimetidine, clarithromycin, cyclophosphamide, cyclosporine, dicumarol, diuretics, docetaxel, estrogens, grapefruit juice, indomethacin, influenza vaccines, itraconazole, ketoconazole, lansoprazole, live vaccines, methotrexate, montelukast, omeprazole, oral contraceptives, pancuronium, phenobarbital, phenytoin, ranitidine, rifampicin, rifampin, timolol, tolbutamide, vitamin A... 

Noninterfering acetaminophen, aspirin, 5-azacytidine, baclofen, cimetidine, cyclophosphamide, cyclosporin A, famotidine, 5-duorouracil, ranitidine, verapamil... 

Ranitidine, and probably famotidine, appear not to increase the bone marrow toxicity of cyclophosphamide. Animal studies suggest that cimetidine might. 

Alberts DS, Mason-Liddil N, Plezia PM, Roe DJ, Dorr RT, Struck RF, Fliillips JG. Lack of ranitidine effects on cyclophosphamide lx ne marrow toxicity or metabolism a placebo-controlled clinical trial. J Natl Cancer Inst 99 ) 83, 1739-43. 

Dorr RT, Soble MJ, Alberts DS. Interaction of cimetidine but not ranitidine with cyclophosphamide in mice. Cancer Res (1986) 46,1795-9. 

Noninterfering amitriptyline, carbamazepine, carmustine, chlorpromazine, cimeti-dine, cisplatin, cyclophosphamide, dexamethasone, diazepam, digoxin, etoposide, furo-semide, haloperidol, ibuprofen, imipramine, indomethacin, methotrexate, phenobarbi-tal, phen3doin, propranolol, ranitidine, theophylline, triazolam, warfarin... 

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