Cyclopentolate

Review Problem 8 Suggest a synthesis of the mydriatic (dilates the pupils of tlie eyes) cyclopentolate, TM 110. [Pg.34]

Cyclopentamine HCI Cyclopentolate HCI Cyclopentyl bromide Ketamine HCI Quinestrol... [Pg.1626]

C4H10CIN 107-99-3) see Bephenium hydroxynaphthoate Binedaline Brompheniramine Captodiame Carbinoxamine Chlorphenamine Chlorphenoxamine Cyclopentolate Dibenzepine Diltiazem Dimetindene Doxylamine Ethoheptazine Itopride hydrochloride Meclofenoxate Mepyramine Moxisylyte Normethadone Noxiptiline Pheniramine Phenyltoloxamine Tamoxifen Toremifene Trimethobenzamide Tripelennamine Zotepine... [Pg.2361]

The answer is c. (Hardman, pp 156-158.) A wide variety of clinical conditions are treated with antimuscarinic drugs. Dicyclomine hydrochloride and methscopolamine bromide are used to reduce Gl motility, although side effects—dryness of the mouth, loss of visual accommodation, and difficulty in urination—may limit their acceptance by patients. Cyclopentolate hydrochloride is used in ophthalmology for its mydriatic and cycloplegic properties during refraction of the eye. Trihexyphenidyl hydrochloride is one of the important antimuscarinic compounds used in the treatment of parkinsonism. For bronchodilation in patients with bronchial asthma and other bronchospastic diseases, ipratropium bromide is used by inhalation. Systemic adverse reactions are low because the actions are largely confined to the mouth and airways. [Pg.189]

Saettone et al. [62] evaluated low viseosity polymers (polygalacturonic acid, hyaluronic acid, carboxymethylamylose, carboxymethylchitin, chondroitin sulfate, heparan sulfate, and mesoglyean) as potential mucoadhesive carriers for cyclopentolate and pilocarpine in a study of their influence on miotic activity in rabbits. Small but significant increases in bioavailability were observed and a correlation was foimd between the bioavailability of the two drugs and the mucoadhesive bond strength of the polymers investigated. [Pg.182]

Cycloguanil, 281 Cyclomethycaine, 14 Cyclopal, 269, 270 Cyclopentamine, 37 Cyclopenthiazide, 358 Cyclopentolate, 92 Cyclopropylcarbynyl-homoallyl rearrangement, 31, 151, 182 Cyclopyrazolate, 92 3,5-Cyclosteroid, 182 Cy do thiazide, 358 Cycrimine, 47 Cyproheptadine, 151... [Pg.479]

Cyclopentolate Cyclopentolate, 2-(dimethylamino)ethylic ester of 1-hydroxycyclopentane-a-phenylacetic acid (14.1.39), is synthesized by the esterification of a-(l- droxycylopentyl) phenylacetic acid (14.1.38) using 2-dimethylaminoethylchloride, a-(l- Hydroxycyclopentyl) phenylacetic acid (14.1.38) is synthesized by reacting the sodium salt of phenylacetic acid with cyclopentanone in the presence of isopropylmagnesium bromide [30]. [Pg.204]

Cyclopentolate is an effective mydriatic and cycloplegic that begins to act very quickly and has a relatively short duration. It is used also in ophthalmoscopy for causing pre-operational mydriasis. Synonyms of this drag are mydrilate, cyclogyl, cyclomydril, pentolair, and others. [Pg.204]

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