Cyclopentenyl cytosine

In 1976, Theeuwes and Yum described an implantable slow-flow (0.5-1 pL/h) osmotic minipump for the local delivery of drugs [8], Because of their simplicity and reliability [9, 10], osmotic pumps seem suitable for the chronic delivery of chemotherapy. In 1982, Kroin and Penn coupled the minipump to a stainless steel cannula to examine the intracerebral infusion of cisplatin [11]. They used a similar system to demonstrate the efficacy of intratumoral cisplatin and fluorouracil against a 9L rat cerebellar tumor model [12]. Subsequently, efficacy against other CNS tumor models has been observed with infusions of bleomycin [13], phenyl acetate [14], topotecan [15], cyclopentenyl cytosine [16], and carboplatin [17],... 

Viola JJ, Agbaiia A, Walbridge S, Oshiro EM, Johns DG, Kelly JA, Oldfield EH, Ram Z (1995) In situ cyclopentenyl cytosine infusion for the treatment of experimental brain tumors. Cancer Res 55 1306-1309. 

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