Cyclopentanone monooxygenases

Cyclohexanone and Cyclopentanone Monooxygenases as Baeyer-Villigerases and Sulfoxidation Catalysts... [Pg.48]

Figure 3 Illustration of overlapping substrate specificities of four BVMOs. Cyclohexanone monooxygenase (CHMO), cyclopentanone monooxygenase (CPMO), 4-hydroxyacetophenone monooxygenase (HAPMO) and phenylacetone monooxygenase (PAMO). For each enzyme, several typical substrates are...

Cyclohexanone and cyclopentanone monooxygenases have been used in the microbial BV oxidation of prochiral bicycloketones. A significant difference in behaviour of [3.3.0] and [4.3.0] substrates has been analysed by high-level DFT calculations.345 Al-BINOL complexes catalyse the enantioselective BV oxidation of cyclobutanones to give the corresponding y-butyrolactones in up to 84% ee.346 Advances in the enantioselective metal-catalysed reaction have been reviewed, especially for lactone preparation.347... [Pg.43]

More recently, the formal total syntheses of some bioactive natural products bearing a tetrahydrofurane moiety were achieved by enzymatic Baeyer-Villiger oxidation using cyclopentanone monooxygenases (CPMOs) from Comamonas sp. [Pg.24]

Cyclopentanone monooxygenase Pseudomonas NCIMB 9872 1 3-4 identical subunits NADPH 200 (54-58 each) 1 FAD per subunit 7.7 [48]... [Pg.1215]

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