Cyclooxygenase activity/inhibition resveratrol

MacCarrone, M., Lorenzon, T., Guerrieri, P., and Agro, A.F., Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity, Eur. J. Biochem., 265 (1), 27-34,1999. 

Finally, in contrast to the apoptotic effect exerted by polyphenols, an antiapoptotic effect, mainly attributed to their ability to scavenge free radicals, has also been observed. For example, resveratrol prevented apoptosis in human erythroleukemia K562 cells (Mac-Carrone et al. 1999) by inhibiting lipoxygenase and cyclooxygenase activity, either directly or indirectly. In addition, tea catechins exerted a neuroprotective effect by inhibiting the 6-hydroxydopamine-induced apoptosis in PC12 cells (Nie et al. 2002). 

The anti-promotion activity was shown by its blocking actimi of the stunuU-mediated MAPK pathway activation, inhibition of polyamine synthesis and increase of polyamine catabolism, and inhibition of the production of proinflammatory mediators via cyclooxygenase-2 and lipoxygenase pathways. Resveratrol may also inhibit NF-kB and AP-1 activation. 

Subbaramaiah K, Chung WJ, Michaluart P, Telang N, Tanabe T, Inoue H, Jang M, Pezzuto JM, Dannenberg AJ. 1998. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J Biol Chem 273 21875-21882. 

Subbaramaial, K., Quing, W., Michaluart, R, Telang, N., Tan-abe, T., Inoue, H., Jang, M., Pezzuto, J.M., and Dannenberg, A.J. (1998) Resveratrol Inhibits Cyclooxygenase-2 Transcription and Activity in Phorbol Ester-Treated Human Mammary Epithehal CeUs, J. Biol. Chem. 273,21875-21882. 

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